Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development.

@article{OShields2014InhibitionOE,
  title={Inhibition of endogenous MTF-1 signaling in zebrafish embryos identifies novel roles for MTF-1 in development.},
  author={Britton O'Shields and Andrew G. McArthur and Andrew Holowiecki and Martin Kamper and Jeffrey L. Tapley and Matthew J. Jenny},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1843 9},
  pages={
          1818-33
        }
}
The metal responsive element-binding transcription factor-1 (MTF-1) responds to changes in cellular zinc levels caused by zinc exposure or disruption of endogenous zinc homeostasis by heavy metals or oxygen-related stress. Here we report the functional characterization of a complete zebrafish MTF-1 in comparison with the previously identified isoform lacking the highly conserved cysteine-rich motif (Cys-X-Cys-Cys-X-Cys) found in all other vertebrate MTF-1 orthologs. In an effort to develop… CONTINUE READING
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