Inhibition of embryonic development by microcystin-LR in zebrafish, Danio rerio.

  title={Inhibition of embryonic development by microcystin-LR in zebrafish, Danio rerio.},
  author={P H Wang and Ming-Shan Chien and Fong-June Wu and Hong-Nong Chou and Shyh-Jye Lee},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={45 3},
Microcystin-LR (MC-LR), a cyanobacterial toxin, is a potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). PP1 and PP2A are critical regulators in embryonic development. However, the effects of MC-LR in embryonic development have been controversial. MC-LR has been demonstrated to be highly toxic in medaka, but not in zebrafish or rabbit embryos. The causes of difference may be due to membrane impermeability that impaired the delivery of MC-LR into cytoplasm of… CONTINUE READING

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