Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics

@article{Beach1986InhibitionOE,
  title={Inhibition of elimination of caffeine by disulfiram in normal subjects and recovering alcoholics},
  author={Cynthia A. Beach and Dennis C. Mays and R. C. Guiler and C H Jacober and Nicholas Gerber},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1986},
  volume={39}
}
The kinetics of caffeine elimination were investigated in 10 normal male subjects and in 11 recovering alcoholics before and during disulfiram dosing. In normal subjects the total body clearance of caffeine declined 30% (142 to 99 ml/min) at the maintenance dose of disulfiram, 250 mg/day, and 29% (161 to 114 ml/min) at the loading dose of 500 mg/day. In recovering alcoholics, the total body clearance decreased from 333 to 253 ml/min, a 24% change. The mean caffeine t½increased 39% and 34% in… 
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  • R. Frye, R. Branch
  • Medicine, Chemistry
    British journal of clinical pharmacology
  • 2002
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The presented work summaries the details of several drugs that decreases the alcohol craving it includes acamprosate calcium, fluoxetine, disulfiram, ondansetron and naltrexone hydrochloride including various methods for quantitative estimation of these drugs in the formulations, bulk drugs and biological fluids.
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