Inhibition of egg production in zebrafish by fluoxetine and municipal effluents: a mechanistic evaluation.

@article{Lister2009InhibitionOE,
  title={Inhibition of egg production in zebrafish by fluoxetine and municipal effluents: a mechanistic evaluation.},
  author={Andrea L Lister and Christine Regan and Jessica Van Zwol and Glen L Van der Kraak},
  journal={Aquatic toxicology},
  year={2009},
  volume={95 4},
  pages={320-9}
}
This study explored the impact of nominal concentrations of ethinylestradiol (EE(2); 10ng/L), fluoxetine (FLU; 0.32, 3.2, 32microg/L), and 1-50% treated municipal effluent on reproduction and liver function in sexually mature female zebrafish over a 7-day period. Compared with the control groups, FLU (32microg/L) and 50% effluent treatment significantly reduced the average eggs spawned by approximately 4.5 and 2 fold, respectively. FLU also decreased ovarian levels of 17beta-estradiol (E(2… CONTINUE READING