Inhibition of efflux of quinolines as new therapeutic strategy in malaria.

@article{Henry2008InhibitionOE,
  title={Inhibition of efflux of quinolines as new therapeutic strategy in malaria.},
  author={Maud Henry and Sandrine Alibert and Christophe Rogier and Jacques Barbe and Bruno Pradines},
  journal={Current topics in medicinal chemistry},
  year={2008},
  volume={8 7},
  pages={
          563-78
        }
}
Plasmodium falciparum is one of the most lethal parasite responsible for human malaria. Until now, the only one solution to counter malaria is the use of antimalarial drugs. Unfortunately, the extensively use of drugs, such as quinolines (i.e. chloroquine, quinine or mefloquine), have led to the emergence of drug resistance. Chloroquine and probably other quinolines act in interfering in the detoxification of hematin in the digestive vacuole. Quinolines are accumulated in P. falciparum… 

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