Inhibition of early stages of HIV-1 assembly by INI1/hSNF5 transdominant negative mutant S6.

@article{Cano2011InhibitionOE,
  title={Inhibition of early stages of HIV-1 assembly by INI1/hSNF5 transdominant negative mutant S6.},
  author={Jennifer Cano and Ganjam V. Kalpana},
  journal={Journal of virology},
  year={2011},
  volume={85 5},
  pages={2254-65}
}
INI1/hSNF5 is an HIV-1 integrase (IN) binding protein specifically incorporated into virions. A truncated mutant of INI1 (S6, amino acids 183 to 294) harboring the minimal IN binding Rpt1 domain potently inhibits HIV-1 particle production in a transdominant manner. The inhibition requires interaction of S6 with IN within Gag-Pol. While INI1 is a nuclear protein and harbors a masked nuclear export signal (NES), the transdominant negative mutant S6 is cytoplasmic, due to the unmasking of NES… CONTINUE READING
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Highly Influential
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