Inhibition of eNOS/sGC/PKG Pathway Decreases Akt Phosphorylation Induced by Kainic Acid in Mouse Hippocampus.

@article{Lee2010InhibitionOE,
  title={Inhibition of eNOS/sGC/PKG Pathway Decreases Akt Phosphorylation Induced by Kainic Acid in Mouse Hippocampus.},
  author={Sang Hyun Lee and Jong Seon Byun and Pil Jae Kong and Hee Jae Lee and Duk Kyung Kim and Hae sung Kim and Jong-Hee Sohn and Jae Jun Lee and So Young Lim and Wanjoo Chun and Sung Soo Kim},
  journal={The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology},
  year={2010},
  volume={14 1},
  pages={
          37-43
        }
}
The serine/threonine kinase Akt has been shown to play a role of multiple cellular signaling pathways and act as a transducer of many functions initiated by growth factor receptors that activate phosphatidylinositol 3-kinase (PI3K). It has been reported that phosphorylated Akt activates eNOS resulting in the production of NO and that NO stimulates soluble guanylate cyclase (sGC), which results in accumulation of cGMP and subsequent activation of the protein kinase G (PKG). It has been also… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 28 REFERENCES

Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo.

  • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2003
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Intracerebroventricular injections in mice. Some methodological refinements.

  • Journal of pharmacological methods
  • 1986
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

Kainic Acid-induced Neuronal Death is Attenuated by Aminoguanidine but Aggravated by L-NAME in Mouse Hippocampus.

  • The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2009
VIEW 2 EXCERPTS