Inhibition of dopamine signaling suppresses cGMP accumulation in rd1 retinal organ cultures.

Abstract

The rd1 mouse is a model of retinitis pigmentosa, an inherited photoreceptor neurodegenerative disease. In rd1 retina, early onset rod degeneration is caused by a Pde6b mutation that leads to high levels of intracellular cyclic guanosine monophosphate (cGMP). Cyclic nucleotide-gated ion channels (CNGCs), necessary for phototransduction, are regulated by… (More)
DOI: 10.1097/WNR.0000000000000145

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Cite this paper

@article{Zhang2014InhibitionOD, title={Inhibition of dopamine signaling suppresses cGMP accumulation in rd1 retinal organ cultures.}, author={Ju Zhang and Angela M Richmond and Judith Mosinger Ogilvie}, journal={Neuroreport}, year={2014}, volume={25 8}, pages={601-6} }