Inhibition of direct and indirect TLR-mediated activation of human NK cells by low molecular weight dextran sulfate.

@article{Millard2010InhibitionOD,
  title={Inhibition of direct and indirect TLR-mediated activation of human NK cells by low molecular weight dextran sulfate.},
  author={Anne-Laure Millard and Rolf Spirig and Nicolas J Mueller and J{\"o}rg D Seebach and Robert N. Rieben},
  journal={Molecular immunology},
  year={2010},
  volume={47 14},
  pages={2349-58}
}
NK cells express toll-like receptors (TLR) that recognize conserved pathogen or damage associated molecular patterns and play a fundamental role in innate immunity. Low molecular weight dextran sulfate (DXS), known to inhibit the complement system, has recently been reported by us to inhibit TLR4-induced maturation of human monocyte-derived dendritic cells… CONTINUE READING