Inhibition of diphtheria toxin degradation and cytotoxic action by chloroquine.

  title={Inhibition of diphtheria toxin degradation and cytotoxic action by chloroquine.},
  author={Stephen H Leppla and R B Dorland and John L Middlebrook},
  journal={The Journal of biological chemistry},
  volume={255 6},
Chloroquine was found to prevent the cytotoxic action of diphtheria toxin on cultured monkey kidney cells. Analysis of the cellular processing of 125I-labeled diphtheria toxin showed that chloroquine does not affect the rate or extent of toxin uptake but substantially blocks degradation. These studies provide strong evidence that diphtheria toxin enters monkey kidney cells primarily by adsorptive endocytosis and suggest that lysosomal processing is involved in intracellular activation of the… CONTINUE READING

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