Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine

@article{Almasri2009InhibitionOD,
  title={Inhibition of dipeptidyl peptidase IV (DPP IV) is one of the mechanisms explaining the hypoglycemic effect of berberine},
  author={Ihab M. Al-masri and Mohammad Khalil Mohammad and Mutasem O Tahaa},
  journal={Journal of Enzyme Inhibition and Medicinal Chemistry},
  year={2009},
  volume={24},
  pages={1061 - 1066}
}
Berberine was investigated as an inhibitor of human dipeptidyl peptidase IV (DPP IV) in an attempt to explain its anti-hyperglycemic activities. The investigation included simulated docking experiments to fit berberine within the binding pocket of DPP IV. Berberine was found to readily fit within the binding pocket of DPP IV in a low energy orientation characterized with optimal electrostatic attractive interactions bridging the isoquinolinium positively charged nitrogen atom (berberine) and… 
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