Inhibition of diamine oxidase from porcine kidney by pentamidine and other aminoguanidine compounds.

Abstract

1. Three bisguanidine compounds (those of pentamidine, streptidine and phenformin) were compared for their in vitro inhibitory capacity on diamine oxidase activity (EC 1.4.3.6), the first enzyme of putrescine degradation. 2. Pentamidine was the most potent inhibitor, and phenformine the weaker. Two and a half micromoles of pentamidine was enough to reduce… (More)

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