Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products.

@article{Kaji2007InhibitionOD,
  title={Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products.},
  author={Yuichi Kaji and Tomohiko Usui and Susumu Ishida and Kenji Yamashiro and Tara C. B. Moore and Jonathan R Moore and Yasuhiko Yamamoto and Hiroshi Yamamoto and Anthony P. Adamis},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 2},
  pages={
          858-65
        }
}
PURPOSE The interaction of advanced glycation end products (AGEs) with their receptors is hypothesized to be involved in the development of diabetic retinopathy. In the present study, the role of an AGE receptor, RAGE, was investigated in the development of diabetic retinopathy in vivo. METHODS C57/BJ6 and RAGE-transgenic mice that carried human RAGE genetic DNA under the control of the murine flk-1 promoter were made diabetic with streptozocin. Three months after the onset of diabetes, the… CONTINUE READING

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