Inhibition of diabetes in BB rats by virus infection.

  title={Inhibition of diabetes in BB rats by virus infection.},
  author={Thomas Dyrberg and Peter Lothar Schwimmbeck and Michael B A Oldstone},
  journal={The Journal of clinical investigation},
  volume={81 3},
BB rats serve as a model for human insulin-dependent diabetes mellitus (IDDM), since without insulin treatment, most 60-140-d-old animals die within 1 to 2 wk of developing polyuria, polydypsia, hyperglycemia, and hypoinsulinemia. Lymphoid cells accumulate in the islets of Langerhans and beta cells undergo destruction. We report that inoculation of such BB rats with lymphocytic choriomeningitis virus (Armstrong strain, clone 13) reduces over a prolonged period the incidence of IDDM, normalizes… CONTINUE READING


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