Inhibition of dextransucrase by α-D-Glucose derivatives

  title={Inhibition of dextransucrase by α-D-Glucose derivatives},
  author={Alan G. Michiels and Albert Y. Wang and Douglas S Clark and Harvey W. Blanch},
  journal={Applied Biochemistry and Biotechnology},
Abstractα-D-Glucopyranosyl fluoride was modified at positions 2, 3, or 5 and these analogs were tested as substrates and inhibitors of dextransucrase fromLeuconostoc mesenteroides B-512F. The analogs studied were 2-deoxy-2-fluoro-α-D-glucopyranosyl fluoride, 3-deoxy-3-fluoro-a-D-glucopyranosyl fluoride, 3-deoxy-3-thio-°-D-glucopyranosyl fluoride, and 5-thio-α-D-glucopyranosyl fluoride. Kinetic constants for α-D-glucopyranosyl fluoride were also determined.None of the α-D-glucopyranosyl… CONTINUE READING