Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode, Bursaphelenchus xylophilus.

@article{Lee2008InhibitionOD,
  title={Inhibition of developmental processes by flavone in Caenorhabditis elegans and its application to the pinewood nematode, Bursaphelenchus xylophilus.},
  author={Yong-Uk Lee and Ichiro Kawasaki and Yoongho Lim and W. Oh and Young-Ki Paik and Yhong-Hee Shim},
  journal={Molecules and cells},
  year={2008},
  volume={26 2},
  pages={171-4}
}
Flavone (2-phenyl chromone) is a well-known plant flavonoid, but its bioactivity has been little explored. Treatment of Caenorhabditis elegans or C. brissage with flavones induced embryonic and larval lethality that was pronounced in early larval stages. This anti-nematodal effect was also observed in the pinewood nematode, B. xylophilus. LD(50) values were approximately 100 muM for both B. xylophilus and C. elegans. Our results indicate that flavone is an active nematicidal compound that… CONTINUE READING

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