Inhibition of development of murine melanoma lung metastases by systemic administration of recombinant platelet factor 4.

BACKGROUND When administered locally, recombinant platelet factor 4 (rPF4), a known angiogenesis inhibitor, has been shown to effectively suppress murine melanoma and human colon carcinoma primary tumor growth in mice. It was tentatively concluded that this effect was due to the inhibition of tumor neovascularization. PURPOSE This study has evaluated the… CONTINUE READING