Inhibition of development of abdominal aortic aneurysm by glycolysis restriction.

  title={Inhibition of development of abdominal aortic aneurysm by glycolysis restriction.},
  author={Toshihiro Tsuruda and Kinta Hatakeyama and Shigeki Nagamachi and Yoko Sekita and Sumiharu Sakamoto and George J Endo and Masanori Nishimura and Masakazu Matsuyama and Koichi Yoshimura and Yuko Sato and Toshio Onitsuka and Takuroh Imamura and Yujiro Asada and Kazuo Kitamura},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={32 6},
OBJECTIVE The mechanisms underlying abdominal aortic aneurysm development remain unknown. We hypothesized that acceleration of glucose metabolism with the upregulation of glucose transporters is associated with abdominal aortic aneurysm development. METHODS AND RESULTS Enhanced accumulation of the modified glucose analogue 18 fluoro-deoxyglucose by positron emission tomography imaging in the human abdominal aortic aneurysm was associated with protein expressions of glucose transporters-1 and… CONTINUE READING


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