Inhibition of d-Amino-Acid Oxidase Activity Induces Pain Relief in Mice

  title={Inhibition of d-Amino-Acid Oxidase Activity Induces Pain Relief in Mice},
  author={Wenjuan Zhao and Ryuichi Konno and Xiang-jun Zhou and Ming Yin and Yongxiang Wang},
  journal={Cellular and Molecular Neurobiology},
Abstract(1). We investigated the effects of inhibiting d-amino-acid oxidase (DAO) activity on nociceptive responses through the use of mutant ddY/DAO− mice, which lack DAO activity, and through the application of a selective inhibitor of DAO, sodium benzoate, in the tail flick test, hot-plate test, formalin test, and acetic acid-induced writhing test. (2). Compared with normal ddY/DAO+ mice, ddY/DAO− mice showed significantly prolonged tail withdrawal latency in the tail flick test and licking… 
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