Inhibition of cytokinesis and akt phosphorylation by chaetoglobosin K in ras-transformed epithelial cells

@article{Matesic2005InhibitionOC,
  title={Inhibition of cytokinesis and akt phosphorylation by chaetoglobosin K in ras-transformed epithelial cells},
  author={Diane F. Matesic and Kimberly N. Villio and Stacey L. Folse and Erin L. Garcia and Stephen J. Cutler and Horace G. Cutler},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2005},
  volume={57},
  pages={741-754}
}
Purpose: Chaetoglobosin K (ChK), a bioactive natural product previously shown to have anti-tumor promoting activity in glial cells and growth inhibitory effects in ras-transformed fibroblasts, inhibited anchorage-dependent and anchorage-independent growth in ras-transformed liver epithelial cells. The purpose of this study was to identify cellular targets of ChK that mediate its anti-tumor effects. Methods: Anchorage-independent cell growth assays, using soft agar-coated dishes, and anchorage… CONTINUE READING