Inhibition of cytokine-mediated nitric oxide synthase expression in rat insulinoma cells by scoparone.

@article{Kim2007InhibitionOC,
  title={Inhibition of cytokine-mediated nitric oxide synthase expression in rat insulinoma cells by scoparone.},
  author={Eun Kyung Kim and Kang Beom Kwon and Jae Hyung Lee and Byung Hyun Park and Jin Woo Park and Hern Koo Lee and Eun Chung Jhee and Jeong Yeh Yang},
  journal={Biological & pharmaceutical bulletin},
  year={2007},
  volume={30 2},
  pages={242-6}
}
Cytokines produced by immune cells infiltrating pancreatic islets are important mediators of beta-cell destruction in insulin-dependent diabetes mellitus. Scoparone (6,7-dimethoxycoumarin) is known to have a wide range of pharmacological properties in vitro. In this study, the effects of scoparone on cytokine-induced beta-cell dysfunction were examined. Presence of scoparone significantly protected interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma)-mediated cytotoxicity of RINm5F, a… CONTINUE READING
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