Inhibition of cytokine-driven human immunodeficiency virus type 1 replication by protease inhibitor.

Abstract

Protease inhibitors block virus maturation and prevent the spread of human immunodeficiency virus (HIV)-1 in vitro. HIV-1-positive persons produce higher levels of proinflammatory cytokines that up-regulate HIV-1 replication. For the protease inhibitor to be effective in vivo, it must be able to suppress cytokine-induced HIV-1 replication. The in vitro… (More)

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@article{AlHarthi1997InhibitionOC, title={Inhibition of cytokine-driven human immunodeficiency virus type 1 replication by protease inhibitor.}, author={Lena Al-Harthi and Kim Roebuck and H. Kessler and Alan L. Landay}, journal={The Journal of infectious diseases}, year={1997}, volume={176 5}, pages={1175-9} }