Inhibition of cytochrome P-450 reduces voltage-gated K+ currents in pulmonary arterial myocytes.

@article{Yuan1995InhibitionOC,
  title={Inhibition of cytochrome P-450 reduces voltage-gated K+ currents in pulmonary arterial myocytes.},
  author={X J Yuan and Mary L Tod and Lewis J. Rubin and Mordecai P. Blaustein},
  journal={The American journal of physiology},
  year={1995},
  volume={268 1 Pt 1},
  pages={C259-70}
}
Cytochrome P-450 (P-450) is a NADPH-requiring and O2-dependent monooxygenase system. It is present in lung and has been postulated to act as an O2 sensor in hypoxic pulmonary vasoconstriction. To determine whether P-450 is involved in the regulation of voltage-gated K+ (KV) channel activity in pulmonary artery (PA) myocytes, we used the whole cell patch-clamp technique to evaluate the effects of P-450 inhibitors on KV channel currents (IKV) and membrane potential (Em). Bath application of the P… CONTINUE READING
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