Inhibition of cysteinyl-leukotriene production by azelastine and its biological significance

Abstract

Azelastine is a phthalazinone derivative with a wide spectrum of pharmacological activities. Actively sensitized guinea pigs were used to examine the broncholytic effect of azelastinein vivo. Furthermore, the influence of azelastine on the production of arachidonic acid (AA) metabolites was investigatedin vitro and compared to the effects of… (More)
DOI: 10.1007/BF02028274

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