Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis.

@article{Iwata2007InhibitionOC,
  title={Inhibition of cyclooxygenase-2 suppresses lymph node metastasis via reduction of lymphangiogenesis.},
  author={Caname Iwata and Mitsunobu R Kano and Akiyoshi Komuro and Masako Oka and Kunihiko Kiyono and Erik Johansson and Yasuyuki Morishita and Masakazu Yashiro and Kosei Hirakawa and Michio Kaminishi and Kohei Miyazono},
  journal={Cancer research},
  year={2007},
  volume={67 21},
  pages={10181-9}
}
Cyclooxygenase-2 (COX-2) inhibitor has been reported to suppress tumor progression. However, it is unclear whether this inhibitor can also prevent lymphatic metastasis. To determine the effects of COX-2 inhibitor on lymphatic metastasis, etodolac, a COX-2 inhibitor, was given p.o. to mice bearing orthotopic xenografts or with carcinomatous peritonitis induced with a highly metastatic human diffuse-type gastric carcinoma cell line, OCUM-2MLN. Tumor lymphangiogenesis was significantly decreased… CONTINUE READING