Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production.

@article{Zhang1997InhibitionOC,
  title={Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production.},
  author={Yunhong Zhang and Alex F. Shaffer and Joseph P. Portanova and Karen S. Seibert and Peter C. Isakson},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={283 3},
  pages={
          1069-75
        }
}
PGs derived from cyclooxygenase-2 (COX-2), in particular PGE2, play important roles in the initiation of inflammation and pain. In the present study, we evaluated the role of COX-2-derived PGE2 in an animal model of established hyperalgesia. Inflammation and hyperalgesia were first induced by injection of carrageenan into rat footpads. Then we investigated the effects of subsequent therapeutic treatment with a selective COX inhibitor, with a nonsteroidal anti-inflammatory drug and with anti… CONTINUE READING

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