Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus

  title={Inhibition of cyclooxygenase-2 potentiates retrograde endocannabinoid effects in hippocampus},
  author={Jimok Kim and Bradley E. Alger},
  journal={Nature Neuroscience},
In hippocampal pyramidal cells, a rise in Ca2+ releases endocannabinoids that activate the presynaptic cannabinoid receptor (CB1R) and transiently reduce GABAergic transmission—a process called depolarization-induced suppression of inhibition (DSI). The mechanism that limits the duration of endocannabinoid action in intact cells is unknown. Here we show that inhibition of cyclooxygenase-2 (COX-2), not fatty acid amide hydrolase (FAAH), prolongs DSI, suggesting that COX-2 limits endocannabinoid… CONTINUE READING
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NATURE NEUROSCIENCE Figure 2 Selective COX-2 inhibitors prolong DSI

  • K Tsou
  • Neurosci. Lett. 254,
  • 1998

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