Inhibition of cyclooxygenase-2 improves cardiac function following myocardial infarction in the mouse

Abstract

2 Cyclooxygenase-2 (COX-2) is expressed in the heart in animal models of ischemic injury. Recent studies have suggested that COX-2 products are involved in inflammatory cell infiltration and fibroblast proliferation in the heart. Using a mouse model, we questioned whether a) myocardial infarction (MI) in vivo induces COX-2 expression chronically; and b) COX… (More)

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