Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancer.

@article{Mestre1999InhibitionOC,
  title={Inhibition of cyclooxygenase-2 expression. An approach to preventing head and neck cancer.},
  author={Juan R. Mestre and Georgette G Chan and Fan Zhang and Eun Kyoung Yang and Peter G. Sacks and Jay O. Boyle and Jatin P Shah and David Edelstein and Kotha Subbaramaiah and Andrew J. Dannenberg},
  journal={Annals of the New York Academy of Sciences},
  year={1999},
  volume={889},
  pages={62-71}
}
Cyclooxygenase (COX) catalyzes the formation of prostaglandins (PG) from arachidonic acid. A large body of evidence has accumulated to suggest that COX-2, the inducible form of COX, is important in carcinogenesis. In this study, we determined whether (1) COX-2 was overexpressed in squamous cell carcinoma of the head and neck (HNSCC) and whether (2) retinoids, a class of chemopreventive agents, blocked epidermal growth factor (EGF)-mediated activation of COX-2 expression. Levels of COX-2 mRNA… CONTINUE READING