Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1beta.

@article{Lee2009InhibitionOC,
  title={Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1beta.},
  author={H-S Lee and C-H Lee and Hung-Chin Tsai and Donald Salter},
  journal={Osteoarthritis and cartilage},
  year={2009},
  volume={17 1},
  pages={91-9}
}
OBJECTIVE Investigation of the effects of diallyl sulfide (DAS), a garlic sulfur compound, on joint tissue inflammatory responses induced by monosodium urate (MSU) crystals and interleukin-1beta (IL-1beta). DESIGN The HIG-82 synovial cell line was used to establish the experimental model and DAS regime. Primary cultures of articular chondrocytes and synovial fibroblasts obtained from patients undergoing joint replacement for osteoarthritis were used in experimental studies. Cyclooxygenase… CONTINUE READING
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