Inhibition of cyclooxygenase-2 enhances myocardial damage in a mouse model of viral myocarditis.

@article{Takahashi2005InhibitionOC,
  title={Inhibition of cyclooxygenase-2 enhances myocardial damage in a mouse model of viral myocarditis.},
  author={Takashi Takahashi and Shi-jie Zhu and Hiroyuki Sumino and Seiichiro Saegusa and Takeshi Nakahashi and Kunimitsu Iwai and Shigeto Morimoto and Tsugiyasu Kanda},
  journal={Life sciences},
  year={2005},
  volume={78 2},
  pages={195-204}
}
To determine critical role of cyclooxygenase-2 (COX-2) for development of viral myocarditis, a mouse model of encephalomyocarditis virus-induced myocarditis was used. The virus was intraperitoneally given to COX-2 gene-deficient heterozygote mice (COX-2+/-) and wild-type mice (WT). We examined differences in heart weights, cardiac histological scores, numbers of infiltrating or apoptotic cells in myocardium, cardiac expression levels of COX-2, tumor necrosis factor-alpha (TNF-alpha), and… CONTINUE READING
15 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

Similar Papers

Loading similar papers…