Inhibition of cyclooxygenase-2-dependent survivin mediates decursin-induced apoptosis in human KBM-5 myeloid leukemia cells.

@article{Ahn2010InhibitionOC,
  title={Inhibition of cyclooxygenase-2-dependent survivin mediates decursin-induced apoptosis in human KBM-5 myeloid leukemia cells.},
  author={Quein Ahn and Soo-Jin Jeong and Hyo-Jung O. Lee and H K Kwon and Ihn Han and Hyun Seok Kim and Hyo-Jeong Lee and E E Lee and Kwang Seok Ahn and Min Hyung Jung and Shudong Zhu and Chang-yan Chen and Sung-Hoon Kim},
  journal={Cancer letters},
  year={2010},
  volume={298 2},
  pages={212-21}
}
We demonstrate that decursin induces apoptosis via regulation of cyclooxygenase-2 (COX-2) and survivin in leukemic KBM-5 cells. By activating an apoptotic machinery, decursin is cytotoxic to KBM-5 cells. In this apoptotic process, decursin can activate caspase family members and triggers PARP cleavage. At the same time, the expression of COX-2 and survivin in the cells is downregulated. Furthermore, decursin is in synergy with COX-2 inhibitor, celecoxib or NS398 for the induction of apoptosis… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…