Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication.

  title={Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication.},
  author={Hua Zhu and J P Cong and Deborah Yu and Wade A Bresnahan and Thomas E. Shenk},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={99 6},
Cyclooxygenase 2 (COX-2) mRNA, protein, and activity are transiently induced after infection of human fibroblasts with human cytomegalovirus. Prostaglandin E(2), the product of COX-2 activity, is transiently increased by a factor of >50 in cultures of virus-infected fibroblasts. Both specific (BMS-279652, 279654, and 279655) and nonspecific (indomethacin) COX-2 inhibitors can abrogate the virus-mediated induction of prostaglandin E(2) accumulation. Levels of COX-2 inhibitors that completely… CONTINUE READING