Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin).

@article{Caveda1996InhibitionOC,
  title={Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin).},
  author={Luis Caveda and In{\'e}s Mart{\'i}n-Padura and Paloma Rocha Navarro and Ferruccio Breviario and Monica Corada and Danielle Gulino and Maria Grazia Lampugnani and Elisabetta Dejana},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={98 4},
  pages={886-93}
}
Endothelial cell proliferation is inhibited by the establishment of cell to cell contacts. Adhesive molecules at junctions could therefore play a role in transferring negative growth signals. The transmembrane protein VE-cadherin (vascular endothelial cadherin/cadherin-S) is selectively expressed at intercellular clefts in the endothelium. The intracellular domain interacts with cytoplasmic proteins called catenins that transmit the adhesion signal and contribute to the anchorage of the protein… CONTINUE READING