Inhibition of cortisol biosynthesis decreases circulating leptin levels in obese humans.

@article{DagogoJack2005InhibitionOC,
  title={Inhibition of cortisol biosynthesis decreases circulating leptin levels in obese humans.},
  author={Samuel Dagogo-Jack and Gunjan Tykodi and Indira Umamaheswaran},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2005},
  volume={90 9},
  pages={5333-5}
}
CONTEXT Glucocorticoids increase both appetite and leptin secretion; the hyperleptinemic effect might be a counterregulatory response to the orexigenic effect of glucocorticoids. However, the effect of glucocorticoid inhibition on leptin production has not been reported. OBJECTIVE We tested the hypothesis that if glucocorticoid-induced hyperleptinemia plays a physiological role, then inhibition of endogenous cortisol biosynthesis should decrease leptin secretion. DESIGN A randomized… CONTINUE READING