Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesis.

@article{Kuo2009InhibitionOC,
  title={Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesis.},
  author={Chien-Neng Kuo and L Yang and Cheng-Ta Yang and Chien-Hsiung Lai and Miao-Fen Chen and Ching-Hsein Chen and Chi-Hung Chen and Pei-Chang Wu and H T Kou and Yung-Jen Chen and Chia-Hui Hung and Chong-Bin Tsai},
  journal={Experimental eye research},
  year={2009},
  volume={89 5},
  pages={678-85}
}
The use of Synthetic Amphiphile INTeraction-18 (SAINT-18) carrying plasmid pigment epithelium-derived factor (p-PEDF) as an anti-angiogenesis strategy to treat corneal neovascularization in a rat model was evaluated. Four partially dried forms (Group A: 0 microg, B: 0.1 microg, C: 1 microg, D: 10 microg) of a p-PEDF-SAINT-18 were prepared and implanted into the rat subconjunctival substantia propria 1.5 mm from the limbus at the temporal side. The 1 microg of plasmid-basic fibroblast growth… CONTINUE READING