Inhibition of corneal neovascularization by a peroxisome proliferator-activated receptor-gamma ligand.

@article{Sarayba2005InhibitionOC,
  title={Inhibition of corneal neovascularization by a peroxisome proliferator-activated receptor-gamma ligand.},
  author={Melvin A Sarayba and Li Li and Tulaya Tungsiripat and Norman Liu and Paula M Sweet and Anup J. Patel and Kathryn Elizabeth Osann and Amar G. Chittiboyina and Stephen Carl Benson and Harrihar A. Pershadsingh and Roy S. H. Chuck},
  journal={Experimental eye research},
  year={2005},
  volume={80 3},
  pages={435-42}
}
PURPOSE To determine the efficacy of the peroxisome proliferator-activated receptor gamma agonist, pioglitazone, in inhibiting corneal neovascularization. METHODS Twenty-six adult male Sprague-Dawley rats were randomly divided into three groups. Each group received intrastromal polymer micropellets containing one of the following: Group 1, no active ingredient (n=10); Group 2, vascular endothelial growth factor (VEGF) (n=7); Group 3, VEGF and pioglitazone (n=9). Neovascularization was… CONTINUE READING

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