Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro.

@article{Siwik1999InhibitionOC,
  title={Inhibition of copper-zinc superoxide dismutase induces cell growth, hypertrophic phenotype, and apoptosis in neonatal rat cardiac myocytes in vitro.},
  author={Deborah A. Siwik and John D. Tzortzis and David R. Pimental and Donny L.-F. Chang and Patrick J Pagano and Krishna Singh and Douglas Brian Sawyer and Wilson Steven Colucci},
  journal={Circulation research},
  year={1999},
  volume={85 2},
  pages={147-53}
}
Oxidative stress has been implicated in the pathophysiology of myocardial failure. We tested the hypothesis that inhibition of endogenous antioxidant enzymes can regulate the phenotype of cardiac myocytes. Neonatal rat ventricular myocytes in vitro were exposed to diethyldithiocarbamic acid (DDC), an inhibitor of cytosolic (Cu, Zn) and extracellular superoxide dismutase (SOD). DDC inhibited SOD activity and increased intracellular superoxide in a concentration-dependent manner. A low… CONTINUE READING

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The inactivation of copper-zinc superoxide dismutase by diethyldithiocarbamate

  • RE Heikkila, G. Cohen
  • Circulation Research July
  • 1999

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