Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv.

@article{Thomas1996InhibitionOC,
  title={Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv.},
  author={T C Thomas and Scott Rollins and Russell P. Rother and M. A. Giannoni and Steven Lee Hartman and Eileen A. Elliott and Steven H. Nye and Louis A. Matis and Stephen P. Squinto and Martin John Evans},
  journal={Molecular immunology},
  year={1996},
  volume={33 17-18},
  pages={
          1389-401
        }
}
Activation of the complement system contributes significantly to the pathogenesis of numerous acute and chronic diseases. Recently, a monoclonal antibody (5G1.1) that recognizes the human complement protein C5, has been shown to effectively block C5 cleavage, thereby preventing the generation of the pro-inflammatory complement components C5a and C5b-9. Humanized 5G1.1 antibody, Fab and scFv molecules have been produced by grafting the complementarity determining regions of 5G1.1 on to human… CONTINUE READING

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