Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.

@article{Romano2014InhibitionOC,
  title={Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol.},
  author={Barbara Romano and F. Borrelli and E. Pagano and M. G. Cascio and R. Pertwee and A. Izzo},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year={2014},
  volume={21 5},
  pages={
          631-9
        }
}
  • Barbara Romano, F. Borrelli, +3 authors A. Izzo
  • Published 2014
  • Medicine
  • Phytomedicine : international journal of phytotherapy and phytopharmacology
  • PURPOSE Colon cancer is a major public health problem. Cannabis-based medicines are useful adjunctive treatments in cancer patients. Here, we have investigated the effect of a standardized Cannabis sativa extract with high content of cannabidiol (CBD), here named CBD BDS, i.e. CBD botanical drug substance, on colorectal cancer cell proliferation and in experimental models of colon cancer in vivo. METHODS Proliferation was evaluated in colorectal carcinoma (DLD-1 and HCT116) as well as in… CONTINUE READING
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    References

    SHOWING 1-10 OF 57 REFERENCES
    Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
    • 98
    • PDF
    O-1602, an atypical cannabinoid, inhibits tumor growth in colitis-associated colon cancer through multiple mechanisms
    • 23
    Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
    • 349
    • PDF
    Possible endocannabinoid control of colorectal cancer growth.
    • 263
    • PDF
    Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis.
    • 93
    • PDF
    Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.
    • 108
    • PDF
    Targeting the endocannabinoid system for the treatment of cancer--a practical view.
    • 37
    Cannabidiol as potential anticancer drug
    • 122
    • PDF