Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis.

Abstract

The non-steroidal anti-inflammatory drug, sulindac, inhibits the growth of colorectal tumours in animal models of colon cancer and causes regression of polyps in patients with familial adenomatous polyposis. The mechanism by which sulindac exerts this inhibitory effect is not known, but it has been postulated to be via the inhibition of prostaglandin… (More)

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@article{Charalambous1996InhibitionOC, title={Inhibition of colon cancer precursors in the rat by sulindac sulphone is not dependent on inhibition of prostaglandin synthesis.}, author={Dave Bayer Hara Charalambous and Paul O'Brien}, journal={Journal of gastroenterology and hepatology}, year={1996}, volume={11 4}, pages={307-10} }