Inhibition of colon cancer growth by methylselenocysteine-induced angiogenic chemomodulation is influenced by histologic characteristics of the tumor.

@article{Bhattacharya2009InhibitionOC,
  title={Inhibition of colon cancer growth by methylselenocysteine-induced angiogenic chemomodulation is influenced by histologic characteristics of the tumor.},
  author={Arup Bhattacharya and K{\'a}roly T{\'o}th and Arindam Sen and Mukund Seshadri and Shousong Cao and Farukh A. Durrani and Erik B Faber and Elizabeth A. Repasky and Youcef M. Rustum},
  journal={Clinical colorectal cancer},
  year={2009},
  volume={8 3},
  pages={155-62}
}
Despite an armamentarium that is wide in range, scope of action, and target, chemotherapy has limited success in colorectal cancer (CRC). Novel approaches are needed to overcome tumor barriers to chemotherapy that includes an abnormal tumor vasculature constituting a poor drug delivery system. We have previously shown that 5-methylselenocysteine (MSC) enhances therapeutic efficacy of irinotecan in various human tumor xenografts. We have recently demonstrated that MSC through vascular… CONTINUE READING