Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1

@article{Alaaho2000InhibitionOC,
  title={Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1},
  author={Risto Ala-aho and Nina Johansson and Reidar Axel Grenman and Norbert E. Fusenig and Carlos L{\'o}pez-Ot{\'i}n and V M K{\"a}h{\"a}ri},
  journal={Oncogene},
  year={2000},
  volume={19},
  pages={248-257}
}
Collagenase-3 (MMP-13) is characterized by an exceptionally wide substrate specificity and restricted expression. MMP-13 is specifically expressed by transformed human keratinocytes in squamous cell carcinomas in vivo and its expression correlates with their invasion capacity. Here, we show, that interferon-γ (IFN-γ) markedly inhibits expression of MMP-13 by human cutaneous SCC cells (UT-SCC-7) and by ras-transformed human epidermal keratinocytes (A-5 cells) at the transcriptional level. In… CONTINUE READING
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