Inhibition of collagen synthesis as a treatment for paraquat poisoning.


The effect of L-3, 4-dehydroproline (L-DHP) or DL-3, 4-dehydroproline (DL-DHP) on paraquat-induced pulmonary fibrosis was examined in male rats. Rats that declined in body weight during the 10 days after receiving 7.0 mg paraquat dichloride/kg body weight sc for 7 or 8 days were used. L-DHP or DL-DHP (25 mg/kg) was administered sc daily on days 11 through… (More)