Inhibition of collagen- and ADP-induced platelet aggregation by substance P in vivo: involvement of endothelium-derived relaxing factor.

@article{Humphries1990InhibitionOC,
  title={Inhibition of collagen- and ADP-induced platelet aggregation by substance P in vivo: involvement of endothelium-derived relaxing factor.},
  author={Robert G. Humphries and Wendy Tomlinson and Stephen Eric O'Connor and Paul Leff},
  journal={Journal of cardiovascular pharmacology},
  year={1990},
  volume={16 2},
  pages={292-7}
}
We examined the effect of substance P, a potent stimulator of endothelium-derived relaxing factor (EDRF) release, on responses to collagen and adenosine 3',5'-diphosphate (ADP) in an in vivo model of platelet aggregation. Substance P inhibited platelet aggregation induced in vivo by both collagen and ADP. This anti-platelet effect was particularly pronounced against collagen-induced aggregation and was prevented by prior administration of haemoglobin (Hb), a known inhibitor of EDRF-mediated… CONTINUE READING