Inhibition of coagulation factors by recombinant barley serpin BSZx.

@article{Dahl1996InhibitionOC,
  title={Inhibition of coagulation factors by recombinant barley serpin BSZx.},
  author={S\oren Weis Dahl and S\oren Kj{\ae}rsgaard Rasmussen and Lars Christian Petersen and J\orn Hejgaard},
  journal={FEBS letters},
  year={1996},
  volume={394 2},
  pages={165-8}
}
Barley serpin BSZx is a potent inhibitor of trypsin and chymotrypsin at overlapping reactive sites (Dahl, S.W., Rasmussen, S.K. and Hejgaard, J. (1996) J. Biol. Chem., in press). We have now investigated the interactions of BSZx with a range of serine proteinases from human plasma, pancreas and leukocytes, a fungal trypsin and three subtilisins. Thrombin, plasma kallikrein, factor VIIa/tissue factor and factor Xa were inhibited by BSZx at heparin independent association rates (k(ass)) of 4.5 X… CONTINUE READING
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