Inhibition of clathrin-coated pit assembly by an Eps15 mutant.

  title={Inhibition of clathrin-coated pit assembly by an Eps15 mutant.},
  author={Alexandre Benmerah and M Bayrou and Nadine Cerf-Bensussan and Alice Dautry-Varsat},
  journal={Journal of cell science},
  volume={112 ( Pt 9)},
Recent data have shown that Eps15, a newly identified component of clathrin-coated pits constitutively associated with the AP-2 complex, is required for receptor-mediated endocytosis. However, its precise function remains unknown. Interestingly, Eps15 contains three EH (Eps15-Homology) domains also found in proteins required for the internalization step of endocytosis in yeast. Results presented here show that EH domains are required for correct coated pit targeting of Eps15. Furthermore, when… CONTINUE READING
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