Inhibition of class II histone deacetylase blocks proliferation and promotes neuronal differentiation of the embryonic rat neural progenitor cells.

@article{Liu2012InhibitionOC,
  title={Inhibition of class II histone deacetylase blocks proliferation and promotes neuronal differentiation of the embryonic rat neural progenitor cells.},
  author={Huiling Liu and Hao Wu and Yanxia Wang and Yazhou Wang and Xinhua Wu and Shaoqing Ju and Xiaofei Wang},
  journal={Acta neurobiologiae experimentalis},
  year={2012},
  volume={72 4},
  pages={365-76}
}
Neural precursor cells (NPCs), which are capable of self-renewing, migrating to specific sites, and differentiating into the three main CNS lineages, neurons, astrocytes and oligodendrocytes, have been used experimentally to repair the damaged nervous system, either by grafting of cells grown in vitro or by activating endogenous NPCs. The grafting of NPCs, however, is limited by its lower viability and undesired glial differentiation. Understanding the mechanism underlying these events… CONTINUE READING

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