Corpus ID: 43711389

Inhibition of cis-diamminedichloroplatinum secretion by the human kidney with probenecid.

@article{Jacobs1984InhibitionOC,
  title={Inhibition of cis-diamminedichloroplatinum secretion by the human kidney with probenecid.},
  author={C. Jacobs and C. Norman Coleman and Linda L. Rich and K Hirst and Michael W Weiner},
  journal={Cancer research},
  year={1984},
  volume={44 8},
  pages={
          3632-5
        }
}
  • C. Jacobs, C. Norman Coleman, +2 authors Michael W Weiner
  • Published in Cancer research 1984
  • Medicine
  • The renal handling of cis-diamminedichloroplatinum (CP) was investigated by measuring the renal clearance of creatinine, inulin, and free platinum in ten cancer patients. Free platinum clearances exceeded the glomerular filtration rate in all time periods. For example, at 1 to 2 hr, the mean clearance of free platinum was 224 +/- 32 (S.E.) ml/min compared to a mean creatinine clearance of 94 +/- 15 ml/min or a mean inulin clearance of 94 +/- 17 ml/min (p less than 0.01), indicating secretion of… CONTINUE READING

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