Inhibition of cholinergic response by taurine in frog isolated skeletal muscle

@article{Lehmann1984InhibitionOC,
  title={Inhibition of cholinergic response by taurine in frog isolated skeletal muscle},
  author={Anders Lehmann and Anders Hamberger},
  journal={Journal of Pharmacy and Pharmacology},
  year={1984},
  volume={36}
}
Carbamylcholine‐stimulated contractions of isolated frog gastrocnemius muscle were inhibited in a non‐competitive fashion by 5–25 mm taurine. Taurine had no effect on the resting length of the muscle. Caffeine‐induced contractures were unaffected by taurine which indicates that the sarcoplasmic reticulum is not an important site of action for taurine. A possible functional role for taurine in skeletal muscle is discussed. 

Neural regulation of taurine transport in skeletal muscle.

Experiments with myotonic muscles have shown that taurine prevents or reduces the electrical signs of muscular hyperexcitability and favors potassium accumulation into the muscle fibers, and affects various electrophysiological and biochemical parameters of skeletal muscle.

Regulation of Taurine Transport in Rat Skeletal Muscle

The results suggest that transport of taurine into rat skeletal muscles is regulated differently by neural information and by muscular activity, and that the regulation is dependent on the muscle phenotype.

Antiarrhythmic action of taurine.

The effects of taurine on arrhythmias caused by adrenaline infusion, ischemia-reperfusion injury and veratrine administration in anesthetized rats are examined and the relationship between the antiarrhythmic activity of t aurine and changes in myocardial cAMP and free radical production is explored.

Taurine in normal and diseased human skeletal muscle

Taurine concentration rose slightly with age and tended to be higher in denervations, muscular dystrophies and myotonias, but the differences from the control values were non‐significant.

Electrically-evoked release of taurine in the rat vas deferens: evidence for a purinoceptor-mediated effect

It is concluded that electrical (neural) stimulation releases taurine in rat vas deferens mainly postjunctional in origin, secondary to ATP release from sympathetic axon terminals, and a consequence of postJunctional P2x-purinoceptor activation.

Taurine distribution in the cat muscle: an immunohistochemical study.

Taurine is present in large amounts in every kind of muscle tissue and affects electrophysiological and biochemical parameters including hyperpolarization of muscle fibers and a decrease of the action potential duration.

Taurine content and distribution in equine skeletal muscle.

TAU was positively correlated to type-1 f.s.a. (r = 0.94, p < 0.001) in both post mortem samples and biopsies from horses in race-training and was estimated to be absent from type-2B fibres in both horse groups.

Taurine supplementation regulates pancreatic islet function in response to potentiating agents in leptin-deficient obese mice.

Despite not preventing the development of obesity, the normalization of the cholinergic/PKC pathway and the improvement in the action of Phe, indicate that Tau may regulate the ANS actions upon endocrine pancreas in obesity.

Taurine: a preventive agent of the acute ethanol depletive action on the isolated human amniotic membrane

The preventive action of taurineversus ethanol, on the human amniotic membrane, was exerted on the polar groups of phospholipids, hindering the incorporation of ethanol molecules.

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